CP681301 is a highly potent and specific small molecule inhibitor of CDK5 with an inhibition constant (Ki) of 13.7 nM for CDK5. CP681301 not only completely blocks the kinase activity of CDK5-p35 and CDK5-p25 complexes but also effectively inhibits the expression of stem cell markers (such as SOX2, OLIG2) and the self-renewal capacity of tumor cells in glioma stem cell models, demonstrating anti-tumor proliferative activity.
Molecular Weight:
298.38
CAS Number:
[865317-32-4]
Formula:
C17H22N4O
Target:
CDK|||DNA/RNA Synthesis
T60661
T60661
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