CP681301 is a highly potent and specific small molecule inhibitor of CDK5 with an inhibition constant (Ki) of 13.7 nM for CDK5. CP681301 not only completely blocks the kinase activity of CDK5-p35 and CDK5-p25 complexes but also effectively inhibits the expression of stem cell markers (such as SOX2, OLIG2) and the self-renewal capacity of tumor cells in glioma stem cell models, demonstrating anti-tumor proliferative activity.
Molekulargewicht:
298.38
CAS Nummer:
[865317-32-4]
Formel:
C17H22N4O
Target-Kategorie:
CDK|||DNA/RNA Synthesis
T60661
T60661
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
