GNE-783 is a highly selective CHK1 inhibitor that effectively enhances the antitumor efficacy of gemcitabine. After DNA damage, it inactivates S-phase and G2-phase cell cycle checkpoints, thereby improving the therapeutic effect of antimetabolite DNA-damaging agents. GNE-783 shows selective chemosensitization in different tumors, such as enhancing the antitumor activity of temozolomide only in melanoma cell lines.
Molecular Weight:
368.43
CAS Number:
[1200127-66-7]
Formula:
C22H20N6
Target:
Chk
T27424
T27424
* VAT and and shipping costs not included. Errors and price changes excepted
