GNE-783 is a highly selective CHK1 inhibitor that effectively enhances the antitumor efficacy of gemcitabine. After DNA damage, it inactivates S-phase and G2-phase cell cycle checkpoints, thereby improving the therapeutic effect of antimetabolite DNA-damaging agents. GNE-783 shows selective chemosensitization in different tumors, such as enhancing the antitumor activity of temozolomide only in melanoma cell lines.
Molekulargewicht:
368.43
CAS Nummer:
[1200127-66-7]
Formel:
C22H20N6
Target-Kategorie:
Chk
T27424
T27424
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