TNG961 is a potent, highly selective, CRBN-dependent HBS1L (GSPT3) molecular chaperone inhibitor. By degrading HBS1L, TNG961 specifically disrupts protein homeostasis in FOCAD-deficient cancer cells, thereby inducing growth inhibition and cell death. TNG961 can be used in studies of FOCAD-deficient tumors.
Molecular Weight:
539.57
Formula:
C28H24F3N3O3S
Target:
Molecular Glues
T217526
T217526
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