P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 µM in HT-29 cells. It blocks PAR2-mediated Ca2+ mobilization without affecting signaling through PAR1, PAR4, or ATP. P2L-003 dose-dependently inhibits downstream MAPK signaling cascades, including the phosphorylation of ERK1/2 and p38, and is applicable in colon cancer research.
Molecular Weight:
472.99
CAS Number:
[1359416-20-8]
Formula:
C23H25ClN4O3S
Target:
Protease-activated Receptor|||p38 MAPK
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