P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 µM in HT-29 cells. It blocks PAR2-mediated Ca2+ mobilization without affecting signaling through PAR1, PAR4, or ATP. P2L-003 dose-dependently inhibits downstream MAPK signaling cascades, including the phosphorylation of ERK1/2 and p38, and is applicable in colon cancer research.
Molekulargewicht:
472.99
CAS Nummer:
[1359416-20-8]
Formel:
C23H25ClN4O3S
Target-Kategorie:
Protease-activated Receptor|||p38 MAPK
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
