IKKb Antibody, Rabbit, Polyclonal

Catalog Number: NSJ-R31146

Article Name:	IKKb Antibody, Rabbit, Polyclonal
Biozol Catalog Number:	NSJ-R31146
Supplier Catalog Number:	R31146
Alternative Catalog Number:	NSJ-R31146
Manufacturer:	NSJ Bioreagents
Host:	Rabbit
Category:	Antikörper
Application:	WB
Species Reactivity:	Human, Mouse, Rat
Immunogen:	An amino acid sequence from the C-terminus of human IKK beta (QEMVRLLLQAIQSFEKK) was used as the immunogen for this IKKb antibody (100% mouse homology).

IKBKB (Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Kinase of, Beta), also known as IKKb, NFKBIKB, and IKK2, is a protein that in humans is encoded by the IKBKB gene. Shindo et al.(1998) mapped the gene to chromosome 8p12-p11 by FISH. Mercurio et al.(1997) found that mutations in IKK2/IKKb had a more pronounced effect upon NFKB activation than did comparable mutations in IKK1/IKKa. Yin et al.(1998) tested the activity of various antiinflammatory agents on the IKK complex. They demonstrated that aspirin and sodium salicylate specifically inhibit IKK beta activity in vitro and in vivo by binding to IKK beta to reduce ATP binding.

Clonality:	Polyclonal
UniProt:	O14920
Buffer:	Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Purity:	Antigen affinity
Form:	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:	Primary Antibody

Application Dilute:	Western blot: 0.5-1ug/ml
Application Notes:	The stated application concentrations are suggested starting amounts. Titration of the IKKb antibody may be required due to differences in protocols and secondary/substrate sensitivity.

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