IKKb Antibody, Rabbit, Polyclonal

Artikelnummer: NSJ-R31146

Artikelname:	IKKb Antibody, Rabbit, Polyclonal
Artikelnummer:	NSJ-R31146
Hersteller Artikelnummer:	R31146
Alternativnummer:	NSJ-R31146
Hersteller:	NSJ Bioreagents
Wirt:	Rabbit
Kategorie:	Antikörper
Applikation:	WB
Spezies Reaktivität:	Human, Mouse, Rat
Immunogen:	An amino acid sequence from the C-terminus of human IKK beta (QEMVRLLLQAIQSFEKK) was used as the immunogen for this IKKb antibody (100% mouse homology).

IKBKB (Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Kinase of, Beta), also known as IKKb, NFKBIKB, and IKK2, is a protein that in humans is encoded by the IKBKB gene. Shindo et al.(1998) mapped the gene to chromosome 8p12-p11 by FISH. Mercurio et al.(1997) found that mutations in IKK2/IKKb had a more pronounced effect upon NFKB activation than did comparable mutations in IKK1/IKKa. Yin et al.(1998) tested the activity of various antiinflammatory agents on the IKK complex. They demonstrated that aspirin and sodium salicylate specifically inhibit IKK beta activity in vitro and in vivo by binding to IKK beta to reduce ATP binding.

Klonalität:	Polyclonal
UniProt:	O14920
Puffer:	Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reinheit:	Antigen affinity
Formulierung:	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:	Primary Antibody

Application Verdünnung:	Western blot: 0.5-1ug/ml
Anwendungsbeschreibung:	The stated application concentrations are suggested starting amounts. Titration of the IKKb antibody may be required due to differences in protocols and secondary/substrate sensitivity.

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