Abz-HPGGPQ-EDDnp, CAS [[221055-89-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-P5377
Supplier Catalog Number:
HY-P5377
Alternative Catalog Number:
MCE-HY-P5377-1UNIT
Manufacturer:
MedchemExpress
Category:
Proteine/Peptide
Alternative Names:
Cathepsin K substrate
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)
Molecular Weight:
918.91
CAS Number:
[221055-89-6]
Formula:
C40H50N14O12
Target:
Ser/Thr Protease
Application Notes:
MCE Product type: Peptides
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