Abz-HPGGPQ-EDDnp, CAS [[221055-89-6]] Preis auf Anfrage
Artikelnummer:
MCE-HY-P5377
Hersteller Artikelnummer:
HY-P5377
Alternativnummer:
MCE-HY-P5377-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Proteine/Peptide
Alternative Synonym:
Cathepsin K substrate
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)
Molekulargewicht:
918.91
CAS Nummer:
[221055-89-6]
Formel:
C40H50N14O12
Target-Kategorie:
Ser/Thr Protease
Anwendungsbeschreibung:
MCE Product type: Peptides
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