VHL-IN-1 (Compound 30) is an E3 ligase VHL inhibitor with a Kd value of 37 nM. VHL-IN-1 blocks VHL-mediated ubiquitination and degradation of HIF-1alpha. VHL-IN-1 stabilizes the protein levels of HIF-1alpha and hydroxylated HIF-1alpha, and induces the transcriptional activity of HIF-1alpha. VHL-IN-1 can be used for PROTAC development. VHL-IN-1 is applicable for cancer research[1].
Molecular Weight:
544.68
Purity:
99.84
CAS Number:
[3033117-53-9]
Formula:
C28H37FN4O4S
Target:
E1/E2/E3 Enzyme,HIF/HIF Prolyl-Hydroxylase,Ligands for E3 Ligase
Application Notes:
MCE Product type: Reference compound
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