VHL-IN-1 (Compound 30) is an E3 ligase VHL inhibitor with a Kd value of 37 nM. VHL-IN-1 blocks VHL-mediated ubiquitination and degradation of HIF-1alpha. VHL-IN-1 stabilizes the protein levels of HIF-1alpha and hydroxylated HIF-1alpha, and induces the transcriptional activity of HIF-1alpha. VHL-IN-1 can be used for PROTAC development. VHL-IN-1 is applicable for cancer research[1].
Molekulargewicht:
544.68
Reinheit:
99.84
CAS Nummer:
[3033117-53-9]
Formel:
C28H37FN4O4S
Target-Kategorie:
E1/E2/E3 Enzyme,HIF/HIF Prolyl-Hydroxylase,Ligands for E3 Ligase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
