Chemical Name: 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
Dual necroptosis/ferroptosis inhibitor
Molecular Weight:
210.24
Purity:
>98% by HPLC, NMR (conforms)
Form:
Brown solid
CAS Number:
[1346526-26-8]
Formula:
C13H10N2O
Application Notes:
Sibiriline is a novel dual inhibitor of necroptosis and ferroptosis.1,2 It prevents necroptosis via inhibition of RIPK1 (IC50 = 1.1 µM) and ferroptosis via inhibition of phospholipid peroxidation acting as a radical trapping antioxidant. Sibiriline displayed neuroprotective effects in a mouse model of Parkinsons disease.
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