JAK/HDAC-IN-2 is a dual-targeting 2-amino-4-phenylaminopyrimidine compound that potently inhibits JAK1/2 and HDAC3/6 at nanomolar levels. It induces apoptosis, blocks histone deacetylation and STAT3 phosphorylation, showing robust antiproliferative effects in studies of hematologic cancers and solid tumor models.
Molecular Weight:
570.7
Formula:
C28H38N6O5S
Target:
Apoptosis,HDAC,JAK
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