Compound 6h (Anticancer Agent 139) is a potent tubulin-binding small molecule, engaging Lys352 via pi-cation interaction. It demonstrates high growth inhibition in SNB-19, OVCAR-8, and NCI-H460 cells, with broader moderate activity across multiple other cancer cell lines, supporting its use in anticancer mechanism and cytotoxicity studies.
Molecular Weight:
319.28
Formula:
C16H12F3N3O
Target:
Microtubule Associated,Others
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