WS-383 is a potent and selective small molecule inhibitor of the DCN1-UBC12 protein-protein interaction, exhibiting reversible binding with an IC50 of 11 nM. It serves as a valuable chemical probe for studying cullin neddylation in biochemical and cellular assays, with utility in cancer and developmental biology research.
Molecular Weight:
498.46
Purity:
98.80% (May vary between batches)
CAS Number:
[2247544-02-9]
Formula:
C18H21Cl2N9S2
Target:
E1/E2/E3 Enzyme
Application Notes:
Solubility: DMSO:6.5 mg/mL (13.04 mM)
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