TNFSF9 Antibody - C-terminal region
Catalog Number:
ASB-ARP61434_P050
- Images (3)
| Article Name: | TNFSF9 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-ARP61434_P050 |
| Supplier Catalog Number: | ARP61434_P050 |
| Alternative Catalog Number: | ASB-ARP61434_P050-25UL,ASB-ARP61434_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Human |
| Alternative Names: | CD137L, TNLG5A, 4-1BB-L |
| The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. |



