Functional Fas (human) Antibody, mAb (preservative free), Clone: [APO-1-3], Monoclonal
Catalog Number:
ABT-ADP0026-U050
- Images (0)
| Article Name: | Functional Fas (human) Antibody, mAb (preservative free), Clone: [APO-1-3], Monoclonal |
| Biozol Catalog Number: | ABT-ADP0026-U050 |
| Supplier Catalog Number: | ADP0026-U050 |
| Alternative Catalog Number: | ABT-ADP0026-U050-50UG |
| Manufacturer: | Abcepta |
| Category: | Antikörper |
| Application: | FC, IP, WB |
| Species Reactivity: | Human |
| Alternative Names: | CD95, APO-1, TNFRSF6, Tumor Necrosis Factor Receptor Superfamily Member 6, Apoptosis-mediating Surface Antigen FAS |
| Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappa. |
Product Guarantee and Expert Support
