Functional Fas (human) Antibody, mAb (preservative free), Clone: [APO-1-3], Monoclonal
Artikelnummer:
ABT-ADP0026-U050
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| Artikelname: | Functional Fas (human) Antibody, mAb (preservative free), Clone: [APO-1-3], Monoclonal |
| Artikelnummer: | ABT-ADP0026-U050 |
| Hersteller Artikelnummer: | ADP0026-U050 |
| Alternativnummer: | ABT-ADP0026-U050-50UG |
| Hersteller: | Abcepta |
| Kategorie: | Antikörper |
| Applikation: | FC, IP, WB |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | CD95, APO-1, TNFRSF6, Tumor Necrosis Factor Receptor Superfamily Member 6, Apoptosis-mediating Surface Antigen FAS |
| Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappa. |
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