MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-alpha converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 µM). MMP-9 inhibitor I decreases TNF-alpha secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 µM.
Molekulargewicht:
511.63
CAS Nummer:
[206549-55-5]
Formel:
C27H33N3O5S
Target-Kategorie:
MMP
T37726
T37726
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