Tpl2 Kinase Inhibitor 1 is a potent, reversible, and highly selective ATP-competitive inhibitor of Tpl2 (MAP3K8/COT) serine/threonine kinase, with an IC50 of 50 nM for Tpl2 kinase inhibition. In vitro, Tpl2 Kinase Inhibitor 1 inhibits LPS-induced TNF-alpha release from human primary monocytes (IC50 = 0.7 µM). Tpl2 Kinase Inhibitor 1 can be used in research on inflammatory responses and certain cancers.
Molekulargewicht:
404.83
Reinheit:
98.59%
CAS Nummer:
[871307-18-5]
Formel:
C21H14ClFN6
Target-Kategorie:
MAPK
T17145
T17145
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