A portion of amino acids 60-94 from human Factor XIIIa was used as the immunogen for the Factor XIIIa antibody.
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
The stated application concentrations are suggested starting points. Titration of the Factor XIIIa antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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