Hepatitis C Virus Core, aa2-119, Genotype 3/10, Recombinant (HCV)
Biozol Catalog Number:
USB-H1920-02D
Supplier Catalog Number:
H1920-02D
Alternative Catalog Number:
USB-H1920-02D-100,USB-H1920-02D-1
Manufacturer:
US Biological
Category:
Molekularbiologie
Application:
ELISA, WB
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition,HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. The protein contains the HCV core nucleocapsid immunodominant regions, amino acids 2-119. Specificity: Immunoreactive with sera of HCV-infected individuals Applications: Recombinant HCV Core Antigen may be used in ELISA and Western Blot, excellent for detection of HCV with minimal specificity problems. Storage and Stability: May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity:
95% (SDS-PAGE, Bradford)
Form:
Supplied as a liquid in 1.5M urea, 25mM Tris-HCl, pH 8.0, 0.2% Triton-X, 50% glycerol.
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