Human Chorionic Gonadotropin (HCG) is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the a-and b-subunits. The a-subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP), and HCG but negative for EMA and AFP is probably a choriocarcinoma. Applications: Suitable for use in Immunohistochemistry and RIA. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry (Frozen, Paraffin): Indirect Immunofluorescence analysis on paraffin sections of human pituitaries reveals clear staining of glycoprotein hormone producing cells. Optimal working dilutions to be determined by researcher. Hybridoma: Spleen cells of BALB/c mice fused with the mouse myeloma cell line P3-NS1-Ag4.1. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clonality:
Monoclonal
Clone Designation:
[3H2029 INN-hCG-5]
Purity:
Ascites
Form:
Supplied as a liquid, 0.09% sodium azide.
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