ZCCHC11 (Terminal Uridylyltransferase 4, Zinc Finger, CCHC Domain Containing 11), Rabbit
Catalog Number:
USB-495905
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| Article Name: | ZCCHC11 (Terminal Uridylyltransferase 4, Zinc Finger, CCHC Domain Containing 11), Rabbit |
| Biozol Catalog Number: | USB-495905 |
| Supplier Catalog Number: | 495905 |
| Alternative Catalog Number: | USB-495905-100 |
| Manufacturer: | US Biological |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Immunogen: | Synthetic peptide corresponding to the middle region of human ZCCHC11 |
| ZCCHC11 is the uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3 uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. ZCCHC11 does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3 uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mRNA degradation. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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