IUB0271 (acyl-GIP) is a long-acting acylated glucose-dependent insulinotropic polypeptide (GIP). It enhances cFos neuronal activity in the hypothalamic feeding centers of DIO mouse models and reduces body weight, food intake, and blood glucose levels, effects dependent on CNS-GIPR signaling. IUB0271 is applicable in research on type 2 diabetes (T2DM) and obesity.
Target:
IGF-1R
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