Tat-IKIP (46-60)TFA is the trifluoroacetate salt form of Tat-IKIP (46-60), a transmembrane peptide targeting IkappaB kinase (IKK). It inhibits IKK activation and NF-kappaB target gene expression by disrupting the IKKbeta/NEMO complex. Tat-IKIP (46-60) significantly alleviates DSS-induced acute inflammation in a mouse model of inflammatory bowel disease (IBD) and reduces yeast polysaccharide-induced acute arthritis in an acute arthritis model (AAM). This compound is applicable in the study of inflammatory diseases, such as IBD, pancreatitis, and rheumatoid arthritis.
Target:
NF-kappaB|||IkappaB/IKK
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