Corza6 TFA is a potent and selective peptide inhibitor of the human voltage-gated proton channel (hHv1). It binds to the external voltage-sensor domain (VSD) loop of hHv1 with a dissociation constant (Kd) of approximately 1 nM under the native hyperpolarized resting membrane potential (RMP) of mammalian cells. Additionally, Corza6 TFA induces sperm capacitation and enables continuous reactive oxygen species (ROS) production in white blood cells (WBC).
Target:
ROS|||Proton pump
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