Brittonin A, a methoxylated bibenzyl compound discovered in the liverwort F. inouei, exhibits anticancer properties. It demonstrates cytotoxic effects on KB cells and vincristine-resistant KB/VCR cells with IC50 values of 42.1 and 33.7 µM, respectively, as well as on K562 cells and adriamycin-resistant K562/A02 cells with IC50 values of 49.6 and 30.9 µM, respectively. At a concentration of 5 µM, Brittonin A enhances vincristine-induced cell death in KB/VCR cells and adriamycin-induced cell death in K562/A02 cells.
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