Ssm Spooky Toxin TFA, found in Scolopendra mutilans, effectively inhibits the KCNQ (voltage-gated potassium channel family 7) channels. Its IC50 values for Kv7.4, Kv1.3, and Shal channels are 2.8 µM, 5.26 µM, and 0.1-0.3 M, respectively. This toxin suppresses cytokine production by specifically targeting KV1.3 channels in T cells and plays a crucial role in the centipedes circulatory system.
Target:
Potassium Channel
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