KRAS G12D-IN-35 (example 7) is a potent, orally active inhibitor of KRAS G12D. It effectively suppresses p-ERK in AGS cells and significantly inhibits the proliferation of various KRAS G12D mutant cancer cell lines. Additionally, KRAS G12D-IN-35 reduces tumor growth in HPAC and GP2D mouse models. This compound is applicable for cancer research, including studies on pancreatic and colorectal cancer.
Target:
ERK|||Ras
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