NLRP3-IN-20 is an effective oral inhibitor of NLRP3 inflammatory corpuscles, and the IC50 secreted by IL-1beta is 25nM. NLRP3-IN-20 showed good pharmacokinetic characteristics, and showed significant pharmacological activities in animal models such as nonalcoholic steatohepatitis, septic shock and colitis.
Molecular Weight:
413.53
CAS Number:
[2428478-22-0]
Formula:
C22H27N3O3S
Target:
NOD-like Receptor (NLR)
T79733
T79733
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