FJ9 is an effective Wnt/beta-catenin antagonist (Ki = 29 µM) that downregulates canonical Wnt signaling, inhibits HSC (hepatic stellate cell) activation, and reduces MeCP2 protein levels. FJ9 also disrupts the protein-protein interaction between Frz7 and the DVL PDZ domain, induces apoptosis in human cancer cell lines, and inhibits tumor growth in a mouse xenograft model.
Molecular Weight:
365.47
Purity:
99.60%
CAS Number:
[873841-43-1]
Formula:
C23H27NO3
Target:
Wnt/beta-catenin
T68468
T68468
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