R-HP210 is a selective glucocorticoid receptor modulator (SGRM) that exerts anti-inflammatory activity by acting on the NF-kappaB-mediated inhibitory cross-talk (IC50 = 3.80 µM) without inducing glucocorticoid-mediated transactivation. R-HP210 effectively inhibits the transcription of various LPS-induced pro-inflammatory genes, such as IL-1beta, IL-6, and COX-2.
Molecular Weight:
421.53
Purity:
99.35%
Formula:
C22H19N3O2S2
Target:
NF-kappaB
T62252
T62252
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