HIF-1/2alpha-IN-2 is a selective inhibitor targeting hypoxia-inducible factors 1alpha and 2alpha (HIF-1alpha and HIF-2alpha). It induces a state of cellular iron deficiency by inhibiting the activity of iron-sulfur cluster assembly protein 2 (ISCA2), thereby reducing HIF-2alpha synthesis and ultimately triggering ferroptosis. HIF-1/2alpha-IN-2 is widely used in research related to tumor biology, metabolic regulation, and ischemia.
Molecular Weight:
342.35
CAS Number:
[862974-22-9]
Formula:
C16H11FN4O2S
Target:
HIF
T61102
T61102
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