Pro-PEG3-BA, CAS [[3057939-64-4]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T217157
Supplier Catalog Number:
T217157
Alternative Catalog Number:
TGM-T217157-10MG,TGM-T217157-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Pro-PEG3-BA is a PROTAC degrader targeting EML4-ALK and EGFR, effectively degrading EML4-ALK and EGFR mutants (L858R/T790M) with DC50 values of 0.42 µM and 13.50 µM, respectively. In vitro, it inhibits the proliferation of non-small cell lung cancer cells, inducing cell cycle arrest and apoptosis. Pro-PEG3-BA demonstrates favorable safety characteristics and can reduce EML4-ALK protein expression by modulating the ubiquitin-proteasome system in vivo, making it suitable for research on non-small cell lung cancer.
Molecular Weight:
787.3
CAS Number:
[3057939-64-4]
Formula:
C37H52ClN8O7P
Target:
Apoptosis|||PROTACs|||EGFR|||ALK
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