CAI/II-IN-12 is a potent dual inhibitor of hCAI (IC50= 7.12 µM, Ki= 9.26 µM) and hCAII (IC50= 10.62 µM, Ki= 11.72 µM). It exhibits strong affinity for the active sites of CYP17A1, hCAI, and hCAII enzymes. CAI/II-IN-12 demonstrates rapid conformational stabilization, especially in the CYP17A1 complex, and is applicable in prostate cancer treatment and glaucoma research.
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Carbonic Anhydrase
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