DNDI-0690 is a potent and orally active analogue of DNDI-VL-2098, demonstrating significant efficacy against cutaneous leishmaniasis (CL). It exhibits notable in vitro activity against Leishmania parasites responsible for CL, with an EC50 of 0.17 µM for visceral leishmaniasis and an EC50 of less than 5 µM for the causative parasites of CL. Additionally, DNDI-0690 is effective in a L. major CL mouse model and is applicable for research in CL.
Molecular Weight:
370.34
CAS Number:
[2097881-13-3]
Formula:
C18H15FN4O4
Target:
Parasite
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