TDPAM01 acts as a positive allosteric modulator of the AMPA receptor GluA2. It specifically binds to the ligand-binding domain (LBD) of GluA2, with an IC50 value of 13.4 nM for the GluA2 flop subtype. TDPAM01 stabilizes the active conformation of the GluA2 receptor, delaying receptor inactivation or desensitization, thereby sustaining rapid excitatory synaptic transmission in the central nervous system.
Molecular Weight:
422.52
CAS Number:
[2231103-08-3]
Formula:
C18H22N4O4S2
Target:
iGluR
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