CypD-IN-6 is a potent inhibitor of Cyclophilin D (CypD/PPIF) that effectively suppresses the PPIase activity of CypD (Ki = 32 nM) and binds to CypD (Kd = 60 nM). It is useful for researching diseases associated with the mitochondrial permeability transition pore (MPTP), such as ischemia-reperfusion injury and acute pancreatitis.
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