STING-IN-12 (compound Y2) acts as an inhibitor of STING. It suppresses IFNbeta gene expression induced by SR717 with an IC50 of 0.75 µM. Additionally, STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and by MSA-2 in mice.
Target:
STING
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