Murrayafoline A is a natural carbazole alkaloid found primarily in plants of the genera Murraya and Glycosmis. Murrayafoline A directly targets Specific Protein 1 (Sp1), thereby inhibiting the NF-kappaB and MAPK signaling pathways. Murrayafoline A attenuates the Wnt/beta-catenin pathway by promoting the degradation of intracellular beta-catenin. Murrayafoline A induces G0/G1 phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A enhances contractility and L-type calcium currents in rat ventricular myocytes by activating protein kinase C. Murrayafoline A inhibits LPS-induced neuroinflammation in vivo. Murrayafoline A can be used in research on inflammation, vascular complications, and colorectal cancer.
Molecular Weight:
211.26
Purity:
99.84%
CAS Number:
[4532-33-6]
Formula:
C14H13NO
Target:
p38 MAPK|||NF-kappaB
T124835
T124835
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