GB-88 is an orally active, highly selective, non-peptide PAR2 antagonist that blocks downstream inflammatory and pain signaling pathways by inhibiting PAR2-mediated Ca release (IC50 = 2 µM). GB-88 exhibits antagonistic activity against various PAR2 agonists, including trypsin, SLIGRL-NH2, and GB110, and shows no significant cross-reactivity with PAR1, PAR3, or PAR4. GB-88 is suitable for research into diseases such as inflammation, pain, and metabolic disorders.
Molecular Weight:
546.7
CAS Number:
[1416435-96-5]
Formula:
C32H42N4O4
Target:
Protease-activated Receptor
T11370
T11370
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