DI-591 is a potent, high-affinity, cell-penetrant inhibitor of the DCN1-UBC12 interaction. It binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively, while showing little to no binding to DCN3, DCN4, and DCN5. DI-591 selectively inhibits neddylation of cullin 3 without significant or only weak effects on other cullin family members.
Molecular Weight:
585.8
CAS Number:
[2245887-38-9]
Formula:
C31H47N5O4S
Target:
E1/E2/E3 Enzyme
T11033
T11033
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