Indole-2-carboxylic acid is an indole carboxylic acid compound with multi-target biological activity, exhibiting neuroprotective, antiviral, and antioxidant properties. Indole-2-carboxylic acid is a competitive antagonist at the glycine site of the NMDA receptor (Ki = 15 µM). Indole-2-carboxylic acid specifically inhibits the potentiating effect of glycine on NMDA-gated currents, blocking the neurotoxicity caused by excessive NMDA receptor activation, and can be used in research on the treatment of neurodegenerative diseases and cerebral ischemic injury. Indole-2-carboxylic acid is also an HIV-1 integrase inhibitor, it interferes with the integration of viral DNA into the host genome and can be used in the development of anti-HIV drugs.
Molecular Weight:
161.16
Purity:
99.37%
CAS Number:
[1477-50-5]
Formula:
C9H7NO2
Target:
HIV Protease|||NMDAR
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