DNA Ligase 1 Antibody / LIG1, Clone: [1A9], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V7924-100UG
Supplier Catalog Number:
V7924-100UG
Alternative Catalog Number:
NSJ-V7924-100UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
ELISA, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Full-length native cow LIG1 protein was used as the immunogen for the DNA Ligase 1 antibody.
DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5 phosphoryl and 3 hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. Furthermore, DNA Ligase I antisense ODNs syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme.
