An amino acid sequence from the C-terminus of human Aquaporin 10 (SELETPASAQMLECKL) was used as the immunogen for this Aquaporin 10 antibody.
Aquaporin 10 (AQP10) was identified in human small intestine. This gene encoded a 264-amino-acid protein with high sequence identity with AQP3 (53%), -9(52%), and -7(43%). These AQPs constitute one subfamily of AQP family that is differentiated from the other subfamily of AQP (AQP0, 1, 2, 4, 5, 6, and 8) by sequence homology. In situ hybridization analysis demonstrated highest expression of AQP10 in absorptive epithelial cells at the tips of villi in the jejunum. SDS-PAGE analysis showed expression of a 28-kD protein, similar to its predicted size as well as to that of the other AQPs. Functional analysis indicated that cells expressing AQP10 are permeable to relatively low amounts of water, but, unlike AQP3, -7, and -9, are not permeable to urea or glycerol.
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Purity:
Antigen affinity
Form:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 0.5-1ug/ml
Application Notes:
The stated application concentrations are suggested starting amounts. Titration of the Aquaporin 10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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