An amino acid sequence from the C-terminus of human SPARC-Like Protein 1 (HCFGIKEEDIDENLLF) was used as the immunogen for this SPARCL1 antibody (100% homologous in human, mouse and rat).
SPARCL1 (SPARC-Like Protein 1), also known as HEVIN, is a protein that in humans is encoded by the SPARCL1 gene. The cells in high endothelial venules (HEVs) in lymphoid tissues have a plump, almost cuboidal, appearance and support high levels of lymphocyte extravasation from blood, possibly due to the presence of desmosome-like junctions rather than tight junctions in the HEVs. In chronic inflammation, the activated endothelium of nonlymphoid tissues acquires an HEV-like morphology and function. Hevin is highly expressed in HEV and is though to contribute to the induction or maintenance of features of the HEV endothelium that facilitate lymphocyte migration(Girard and Springer, 1995).
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Purity:
Antigen affinity
Form:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 0.5-1ug/ml,IHC (FFPE): 0.5-1ug/ml
Application Notes:
The stated application concentrations are suggested starting amounts. Titration of the SPARCL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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