An amino acid sequence from the N-terminus of human Chemokine CXC Motif Receptor 1 (DEDYSPCMLETETLN) was used as the immunogen for this CXCR1 antibody.
Chemokine CXC Motif Receptor 1, also known as IL8R, is the receptor for IL8. Morris et al.(1992) mapped the gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Binding of IL-8 to its receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. CXCR1 binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 0.5-1ug/ml,Flow cytometry: 1-3ug/million cells
Application Notes:
The stated application concentrations are suggested starting amounts. Titration of the CXCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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